Our client is a leading global Contract Development and Manufacturing Organization (CDMO) specialising in biologics. With world-class facilities and a strong commitment to innovation, quality, and customer partnership, they deliver end-to-end biologics development and manufacturing solutions - from early-stage cell line development to large-scale commercial production.
The Opportunity
An exceptional leadership opportunity to shape and drive the development of cutting-edge ADC (Antibody–Drug Conjugate) linker-drug conjugation processes within a growing biopharmaceutical organization. The successful candidate will design and implement strategies for conjugation process development, optimize reaction and purification methods, and lead the technology transfer from laboratory to GMP clinical manufacturing scale.
Key Responsibilities
- Lead and design the strategy for developing ADC linker-drug conjugation processes, including handling of small molecule intermediates.
- Plan and execute experiments to optimize conjugation reaction conditions to improve conjugation efficiency, product yield, and critical quality attributes
- Develop and establish robust, scalable purification processes for conjugated ADCs (e.g., Tangential Flow Filtration, Chromatography).
- Lead the technology transfer of conjugation processes from lab scale to pilot and GMP clinical manufacturing scale.
- Lead, motivate, and develop a high-performing team of conjugation process development scientists and engineers
Ideal Candidate
- Hands-on experience in ADC conjugation as well as purification process development and scale-up.
- Prior experience in MSAT and technology transfer for large-scale production is a strong plus.
- Experience in ADC conjugation R&D, process development, or technology transfer, or experience in downstream biopharmaceutical process development.
- Familiar with biopharmaceutical CMC processes, conjugation chemistry, and process development; proficiency in protein purification and chromatography system operation.