主要职责:
负责制定自免疾病开发策略,开展创新性的新项目立项和靶点验证,带领团队推进免疫管线项目至PCC及临床前开发。
· Develop and execute a strategic roadmap for immunology research, with a focus on I&I diseases (e.g., inflammatory bowel disease, atopic dermatitis, chronic spontaneous urticaria, asthma, COPD, multiple sclerosis, or other relevant indications).
Identify and prioritize high-value therapeutic targets and disease areas based on unmet medical needs, scientific feasibility, and market potential.
· Advance I&I projects as a project leader to PCC or further stages. Oversee the design and execution of preclinical studies to validate targets, evaluate candidate molecules, characterize their mechanism of action in relevant assays, and evaluate efficacy, safety, and PK/PD leveraging internal capabilities and CRO network.
· Collaborate with cross-functional teams to advance projects, including upstream and downstream teams such as antibody discovery/protein engineering, and CMC.
· Lead, manage, and mentor the Immunology team, ensuring smooth daily operation and people management, fostering a culture of innovation, collaboration, and scientific excellence, and meeting company's overall strategic goals.
任职要求:
教育背景:
Ph.D. in immunology or equivalent
相关经验:
+8 year post-degree industrial experience and a track record of independent research
语言要求:
Exceptional communication skills in English, with the ability to present complex scientific concepts to both technical and non-technical stakeholders
专业技能:
· Direct working experience in multiple R&D projects, with at least one project serving as a project team leader to complete the Concept-to-PCC cycle in early stage
research. Familiar with the key aspects of defining a successful biotherapeutic molecule.
· A deep understanding of immune system biology (e.g., Type 1, 2, and 17 inflammation, immune checkpoint, or immune regulation/tolerance) and mechanisms
of I&I diseases.
· Proficiency in current and emerging treatment paradigms for I&I diseases, including small molecules, biologics (e.g., monoclonal antibodies, bispecific antibodies,
cytokines), and novel modalities.
· Strong strategic thinking and ability to translate scientific insights into actionable research plans.
通用能力:
· Excellent leadership, team management, and mentorship skills, with a track record of building high-performing teams.
· Must be able to work in a team environment and have good interpersonal skills.