A well-funded Third Rock Ventures Stealth Mode start up is seeking a talented Director to serve as an internal expert and build the
in vivo
pharmacology function in our company. Reporting to the CSO, you will lead and be responsible for strategy, design and execution of the
in vivo
pharmacology work across multiple programs. This role is based in Shanghai and will work closely with our local team as well as be a key interface for our U.S. team.
The Role
We seek an experienced and innovative
in-vivo
/translational pharmacologist with drug discovery expertise in metabolic diseases. The successful candidate will be responsible for the design, execution, and interpretation of complex
in vivo
studies to advance drug discovery from target concept to development stage. The candidate will work closely with program stakeholders in biology, protein and non-clinical sciences and other multidisciplinary scientists to develop and execute strategies for critical animal studies to advance a diverse portfolio of antibody modalities targeting metabolic dysfunction and its complications, obesity and other related disorders. This position requires a demonstrated track record of successful innovative thinking and leadership in the advancement of drug discovery programs.
What You Will Do
- Develop and lead
in vivo
pharmacology studies to gain understanding of primary and secondary pharmacology mechanisms, translational potential, and safety for discovery- and development-stage programs. - Design and execution of optimization paradigms, experimental planning, oversight in the development of new experimental protocols and procedures, and management and analysis of resulting experimental data.
- Implement and apply a variety of technologies to study metabolic dysregulation, muscle/adipose physiology and pharmacology.
- Design, execute, and report/summarize studies with novel molecules that demonstrate detailed proof of concept and proof of mechanism.
- Establish PK/PD relationships in non-clinical species.
- Provide scientific leadership and management of internal resources and external collaborations to characterize the action of novel molecules and place the results into a therapeutic context.
- Ensure high-quality data generation, analysis, and reporting to project teams, governance bodies, and regulatory agencies, and manage key timelines and milestones.
- Contribute and serve as an author for pre-clinical and clinical reports/documents.
Essential Knowledge, Skills and Abilities
- Requires an advanced degree, such as PhD, with demonstrable expertise in
in vivo
physiology, pharmacology, or related discipline (relevant industrial experience is critical). - 10+ years experience in a relevant laboratory setting.
- Demonstrated record of achievement in bringing discovery drug programs from concept through to selection of development candidate to IND submission.
- Significant hands-on experience with execution of animal studies related to the evaluation of metabolic dysregulation, muscle/adipose physiology and
in vivo
pharmacology.